I dont think there is any scientific evidance specifically relating to fish and nutrional recognition... just the 'research' anglers have been doing over the last 30 odd years.
Im not sure how valid the aquaculture indusrty is in terms of HNV baits either.. Im sure they would laugh at the thought of having to paying £1 a kilo.. let alone 10..
I believe there are research papers that prove animals will take advantage of foods rich in vitamin lacking from they're normal diet...
In simple terms Roobish.. and Im no bait buff..
If you can provide fish with a food (bait) in quantity over a period of time, that doesn't crawl under gravel, hide in weed or bury itself in silt, and fulfills all of they're dietary requirements, to my way of thinking they will take advantage of it.
If you were given the choice of going out and hunting for, and then having to cook your food, or having someone do it for you...........